Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

• Main Authors: Ali Koskela (Author), Federico Manai (Author), Filippo Basagni (Author), Mikko Liukkonen (Author), Michela Rosini (Author), Stefano Govoni (Author), Massimo Dal Monte (Author), Adrian Smedowski (Author), Kai Kaarniranta (Author), Marialaura Amadio (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antioxidant systems play key roles in many elderly diseases, including age-related macular degeneration (AMD). Oxidative stress, autophagy impairment and inflammation are well-described in AMD, especially in retinal pigment epithelial (RPE) cells. The master regulator of antioxidant defense Nrf2 has...