Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

Abstract Background Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination tre...

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Main Authors: Christian W. Wichmann (Author), Yit Wooi Goh (Author), Adam C. Parslow (Author), Angela Rigopoulos (Author), Nancy Guo (Author), Andrew M. Scott (Author), Uwe Ackermann (Author), Jonathan M. White (Author)
Format: Book
Published: SpringerOpen, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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