Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone

• Główni autorzy: Christian W. Wichmann (Autor), Yit Wooi Goh (Autor), Adam C. Parslow (Autor), Angela Rigopoulos (Autor), Nancy Guo (Autor), Andrew M. Scott (Autor), Uwe Ackermann (Autor), Jonathan M. White (Autor)
• Format: Książka
• Wydane: SpringerOpen, 2020-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary resistance being major obstacles. Due to the substantial involvement of mTOR kinase in cell growth and proliferation pathways it is now targeted in combination tre...