N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation

• Main Authors: Wei-Yi Li (Author), Wei-Wei Ni (Author), Ya-Xi Ye (Author), Hai-Lian Fang (Author), Xing-Ming Pan (Author), Jie-Ling He (Author), Tian-Li Zhou (Author), Juan Yi (Author), Shan-Shan Liu (Author), Mi Zhou (Author), Zhu-Ping Xiao (Author), Hai-Liang Zhu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which act as effective urease inhibitors with very low cytotoxicity. On...