Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

• Main Authors: Jin Lei (Author), Peng Xiang (Author), Shengmei Zeng (Author), Le Chen (Author), Lei Zhang (Author), Zhiyi Yuan (Author), Jun Zhang (Author), Tingting Wang (Author), Ruihong Yu (Author), Wanping Zhang (Author), Issa Issoufou Ibrahim (Author), Limei Ma (Author), Chao Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive. Vascular glycocalyx coating on the endothelium would be damaged and caused endothel...