Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria.

• Main Authors: Wen-Qiang He (Author), Ahmad Rushdi Shakri (Author), Rukmini Bhardwaj (Author), Camila T França (Author), Danielle I Stanisic (Author), Julie Healer (Author), Benson Kiniboro (Author), Leanne J Robinson (Author), Micheline Guillotte-Blisnick (Author), Christèle Huon (Author), Peter Siba (Author), Alan Cowman (Author), Christopher L King (Author), Wai-Hong Tham (Author), Chetan E Chitnis (Author), Ivo Mueller (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The Plasmodium vivax Duffy Binding Protein (PvDBP) is a key target of naturally acquired immunity. However, region II of PvDBP, which contains the receptor-binding site, is highly polymorphic. The natural acquisition of antibodies to different variants of PvDBP region II (PvDBPII), includ...