Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors

• Glavni autori: Juntao Li (Autor), Yue Wu (Autor), Xinxin Yu (Autor), Xinyu Zheng (Autor), Jiechen Xian (Autor), Senjie Li (Autor), Wanyin Shi (Autor), Yun Tang (Autor), Zhe-Sheng Chen (Autor), Guixia Liu (Autor), Shen Yao (Autor), Jian Xu (Autor), Xiangwei Zheng (Autor)
• Format: Knjiga
• Izdano: BMC, 2022-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background As known, inhibition of phosphodiesterase 5 (PDE5) has the therapeutic effect on male erectile dysfunction (ED), and the processed folium of Epimedium sagittatum Maxim. (PFES) characterized by 8-isopentenyl flavonoids is a famous herb for treating ED. However, the main flavonoids...