Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors

• Main Authors: Juntao Li (Author), Yue Wu (Author), Xinxin Yu (Author), Xinyu Zheng (Author), Jiechen Xian (Author), Senjie Li (Author), Wanyin Shi (Author), Yun Tang (Author), Zhe-Sheng Chen (Author), Guixia Liu (Author), Shen Yao (Author), Jian Xu (Author), Xiangwei Zheng (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background As known, inhibition of phosphodiesterase 5 (PDE5) has the therapeutic effect on male erectile dysfunction (ED), and the processed folium of Epimedium sagittatum Maxim. (PFES) characterized by 8-isopentenyl flavonoids is a famous herb for treating ED. However, the main flavonoids...