Trastuzumab-Coated Nanoparticles Loaded With Docetaxel for Breast Cancer Therapy

• Main Authors: Xueyan Zhang (Author), Jiaxin Liu (Author), Xiangyu Li (Author), Fang Li (Author), Robert J. Lee (Author), Fengying Sun (Author), Youxin Li (Author), Zongyu Liu (Author), Lesheng Teng (Author)
• Format: Book
• Published: SAGE Publishing, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Docetaxel (DTX) is commonly used for breast cancer treatment. Tween 80 used for DTX dissolution in its clinical formulation causes severe hypersensitivity and other adverse reactions. In this study, trastuzumab (Tmab)-coated lipid-polymer hybrid nanoparticles (PLNs) were prepared, composed of poly (...