G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

• Autors principals: Karin J. Bosma (Autor), Mohsin Rahim (Autor), James K. Oeser (Autor), Owen P. McGuinness (Autor), Jamey D. Young (Autor), Richard M. O'Brien (Autor)
• Format: Llibre
• Publicat: Elsevier, 2020-11-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...