G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle determines the sensitivity of glucose-stimulated...
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Autors principals: | , , , , , |
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Format: | Llibre |
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Elsevier,
2020-11-01T00:00:00Z.
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