Age-related changes in DNA methylation levels at CpG sites in bull spermatozoa and in vitro fertilization-derived blastocyst-stage embryos revealed by combined bisulfite restriction analysis

• Main Authors: Kumiko TAKEDA (Author), Eiji KOBAYASHI (Author), Kagetomo NISHINO (Author), Akira IMAI (Author), Hiromichi ADACHI (Author), Yoichiro HOSHINO (Author), Ken IWAO (Author), Satoshi AKAGI (Author), Masahiro KANEDA (Author), Shinya WATANABE (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Age-associated methylation changes in genomic DNA have been recently reported in spermatozoa, and these changes can contribute to decline in fertility. In a previous study, we analyzed the genome-wide DNA methylation profiles of bull spermatozoa using a human DNA methylation microarray and identifie...