Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models

• Main Authors: Yasmen F. Mahran (Author), Amira M. Badr (Author), Layla A. Al-Kharashi (Author), Hanaa N. Alajami (Author), Nouf T. Aldamry (Author), Nervana Moustafa Bayoumy (Author), Elshaymaa I. Elmongy (Author), Sahar Soliman (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: 5-fluorouracil (5-FU) is a widely used, highly effective chemotherapeutic agent. However, its therapeutic efficacy is often limited by associated adverse effects, with hepatotoxicity being frequently reported with 5-FU therapy. Thymol is a monoterpene found in thyme (<i>Thymus vulg...