Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry

• Main Authors: Yingrui Zhang (Author), Shiyu Chen (Author), Fangfang Fan (Author), Ning Xu (Author), Xian-Li Meng (Author), Yi Zhang (Author), Jin-Ming Lin (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aconitine, a common and main toxic component of Aconitum, is toxic to the central nervous system. However, the mechanism of aconitine neurotoxicity is not yet clear. In this work, we had the hypothesis that excitatory amino acids can trigger excitotoxicity as a pointcut to explore the mechanism of n...