Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

• Main Authors: Maliha Zahid (Author), Beth Weber (Author), Ray Yurko (Author), Kazi Islam (Author), Vaishavi Agrawal (Author), Jack Lopuszynski (Author), Hisato Yagi (Author), Guy Salama (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide identified by our prior phage display work. Me...