Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors

• Main Authors: Michaela Keuper (Author), Stephan Sachs (Author), Ellen Walheim (Author), Lucia Berti (Author), Bernhard Raedle (Author), Daniel Tews (Author), Pamela Fischer-Posovszky (Author), Martin Wabitsch (Author), Martin Hrabě de Angelis (Author), Gabi Kastenmüller (Author), Matthias H. Tschöp (Author), Martin Jastroch (Author), Harald Staiger (Author), Susanna M. Hofmann (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondrial dysfunction has been as...