PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

• Main Authors: Lorenzo Monteleone (Author), Andrea Speciale (Author), Giulia Elda Valenti (Author), Nicola Traverso (Author), Silvia Ravera (Author), Ombretta Garbarino (Author), Riccardo Leardi (Author), Emanuele Farinini (Author), Antonella Roveri (Author), Fulvio Ursini (Author), Claudia Cantoni (Author), Maria Adelaide Pronzato (Author), Umberto Maria Marinari (Author), Barbara Marengo (Author), Cinzia Domenicotti (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) are a limited cell population inside a tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol of which cysteine is the limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, a cystine transporter stabilized on ce...