Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

• Главные авторы: Yu-zhou Gui (Автор), Wei Wang (Автор), Qing-qing Wu (Автор), Qi-chen Ding (Автор), Hong-jie Qian (Автор), Qiu-bei Lu (Автор), Ying-jun Zhang (Автор), Yu-lei Zhuang (Автор), Li Deng (Автор), Ying-lin Zuo (Автор), Lin Luo (Автор), Jing-ying Jia (Автор)
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• Опубликовано: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Предметы: article
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Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy volunteers. Sixty-two, eighteen, and forty-eight p...