Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

• Main Authors: Yu-zhou Gui (Author), Wei Wang (Author), Qing-qing Wu (Author), Qi-chen Ding (Author), Hong-jie Qian (Author), Qiu-bei Lu (Author), Ying-jun Zhang (Author), Yu-lei Zhuang (Author), Li Deng (Author), Ying-lin Zuo (Author), Lin Luo (Author), Jing-ying Jia (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy volunteers. Sixty-two, eighteen, and forty-eight p...