Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

• প্রধান লেখক: Yu-zhou Gui (লেখক), Wei Wang (লেখক), Qing-qing Wu (লেখক), Qi-chen Ding (লেখক), Hong-jie Qian (লেখক), Qiu-bei Lu (লেখক), Ying-jun Zhang (লেখক), Yu-lei Zhuang (লেখক), Li Deng (লেখক), Ying-lin Zuo (লেখক), Lin Luo (লেখক), Jing-ying Jia (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy volunteers. Sixty-two, eighteen, and forty-eight p...