Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi.

• Main Authors: Linda J Herrera (Author), Stephen Brand (Author), Andres Santos (Author), Lilian L Nohara (Author), Justin Harrison (Author), Neil R Norcross (Author), Stephen Thompson (Author), Victoria Smith (Author), Carolina Lema (Author), Armando Varela-Ramirez (Author), Ian H Gilbert (Author), Igor C Almeida (Author), Rosa A Maldonado (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of Chagas disease hav...