Impact of CYP2D6 and CYP2B6 phenotypes on the response to tramadol in patients with acute post‐surgical pain

• Main Authors: Ana Casajús (Author), Pablo Zubiaur (Author), Enrique Alday (Author), Paula Soria‐Chacartegui (Author), Miriam Saiz‐Rodríguez (Author), Lara Gutierrez (Author), Catalina Aragonés (Author), Diana Campodónico (Author), Antía Gómez‐Fernández (Author), Marcos Navares‐Gómez (Author), Gonzalo Villapalos‐García (Author), Gina Mejía‐Abril (Author), Dolores Ochoa (Author), Francisco Abad‐Santos (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tramadol is an important minor opioid prescribed for pain management. In this study, we analyzed the well‐known impact of CYP2D6 genetic variation and 60 additional variants in eight candidate genes (i.e., ABCG2, SLCO1B1, CYP2D6, CYP2B6, CYP2C19, CYP2C9, CYP3A5, and CYP3A4) on tramadol effi...