Endothelial cells derived from the blood-brain barrier and islets of Langerhans differ in their response to the effects of bilirubin on oxidative stress under hyperglycemic conditions

• मुख्य लेखकों: Jaime eKapitulnik (लेखक), Clara eBenaim (लेखक), Shlomo eSasson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Unconjugated bilirubin (UCB) is a neurotoxic degradation product of heme. Its toxic effects include induction of apoptosis, and ultimately neuronal cell death. However, at low concentrations, UCB is a potent antioxidant that may protect cells and tissues against oxidative stress by neutralizing toxi...