Endothelial cells derived from the blood-brain barrier and islets of Langerhans differ in their response to the effects of bilirubin on oxidative stress under hyperglycemic conditions

• Main Authors: Jaime eKapitulnik (Author), Clara eBenaim (Author), Shlomo eSasson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Unconjugated bilirubin (UCB) is a neurotoxic degradation product of heme. Its toxic effects include induction of apoptosis, and ultimately neuronal cell death. However, at low concentrations, UCB is a potent antioxidant that may protect cells and tissues against oxidative stress by neutralizing toxi...