Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation

• Główni autorzy: Masahiro Adachi (Autor), Kota Yanagizono (Autor), Yasuhito Okano (Autor), Hitoshi Koizumi (Autor), Isao Uemaetomari (Autor), Keiji Tabuchi (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

ABSTRACTCisplatin-induced ototoxicity is caused by reactive oxygen species. It has been recognized that estradiol (E2) regulates redox balance. However, little is known about the protective mechanisms of E2 against cisplatin-induced ototoxicity. In this study, we investigated the effect of E2 on nuc...