Stearoyl-CoA Desaturase Activity Is Elevated by the Suppression of Its Degradation by Clofibric Acid in the Liver of Rats

• Main Authors: Tomoaki Toyama (Author), Naomi Kudo (Author), Atsushi Mitsumoto (Author), Yasuhide Hibino (Author), Tadashi Tsuda (Author), Yoichi Kawashima (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A mechanism by which fibrates control stearoyl-CoA desaturase (SCD) in the liver was studied. Treatment of rats with 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) or feeding of a fat-free diet markedly elevated hepatic activity of SCD. Both the treatment with clofibric acid and the fee...