Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer's disease

• Main Authors: Changjun Zhang (Author), Yujia Zhang (Author), Yangjing Lv (Author), Jianan Guo (Author), Bianbian Gao (Author), Yi Lu (Author), Anjie Zang (Author), Xi Zhu (Author), Tao Zhou (Author), Yuanyuan Xie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were obser...