Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer's disease

• المؤلفون الرئيسيون: Changjun Zhang (مؤلف), Yujia Zhang (مؤلف), Yangjing Lv (مؤلف), Jianan Guo (مؤلف), Bianbian Gao (مؤلف), Yi Lu (مؤلف), Anjie Zang (مؤلف), Xi Zhu (مؤلف), Tao Zhou (مؤلف), Yuanyuan Xie (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were obser...