The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy

• Main Authors: Zhenzhen Li (Author), Zhen Guo (Author), Rui Lan (Author), Sidong Cai (Author), Zhirong Lin (Author), Jingyan Li (Author), Junjian Wang (Author), Zhuoming Li (Author), Peiqing Liu (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II (Pol II) and leading to transcription elongation....