Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis

• Main Authors: Naozumi eAraragi (Author), Boris eMlinar (Author), Gilda eBaccini (Author), Lise eGutknecht (Author), Klaus-Peter eLesch (Author), Renato eCorradetti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety disorders and depression, as well as in the...