Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity

• Main Authors: Madhu S. Budamagunta (Author), Hidetoshi Mori (Author), Joshua Silk (Author), Ryan R. Slez (Author), Balázs Bognár (Author), Ulises Ruiz Mendiola (Author), Tamás Kálai (Author), Izumi Maezawa (Author), John C. Voss (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The disorder and heterogeneity of low-molecular-weight amyloid-beta oligomers (AβOs) underlie their participation in multiple modes of cellular dysfunction associated with the etiology of Alzheimer's disease (AD). The lack of specified conformational states in these species complicates efforts...