Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of Fonsecaea monophora.

• Main Authors: Minying Li (Author), Huan Huang (Author), Jun Liu (Author), Xiaohui Zhang (Author), Qian Li (Author), Dongmei Li (Author), Mingfen Luo (Author), Xiaoyue Wang (Author), Weiying Zeng (Author), Jiufeng Sun (Author), Hongfang Liu (Author), Liyan Xi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dematiaceous Fonsecaea monophora is one of the major pathogens of chromoblastomycosis. It has been well established that melanization is catalyzed by the type I polyketide synthase (PKS) in F. monophora. Multidomain protein Type I PKS is encoded by six genes, in which the last enzyme thioesterase (T...