Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration

• Main Authors: Chi-Ming Chan (Author), Ponarulselvam Sekar (Author), Duen-Yi Huang (Author), Shu-Hao Hsu (Author), Wan-Wan Lin (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2020-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Oxidative stress-associated retinal pigment epithelium (RPE) cell death is critically implicated in the pathogenesis of visual dysfunction and blindness of retinal degenerative diseases. Sodium iodate (NaIO₃) is an oxidative retinotoxin and causes RPE damage. Previously, we fo...