Effect of the antidiabetic agent pioglitazone on bone metabolism in rats

• Main Authors: Junkichi Kanda (Author), Nobuo Izumo (Author), Yoshiko Kobayashi (Author), Kenji Onodera (Author), Taketoshi Shimakura (Author), Noriaki Yamamoto (Author), Hideaki E. Takahashi (Author), Hiroyuki Wakabayashi (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor gamma (PPARγ) agonists used as therapy for type 2 diabetes. However, clinical studies reported that the therapeutic modulation of PPARγ activity using TZDs may induce negative effects on bone metabolism. This study ai...