Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice

• Main Authors: Holger Henneicke (Author), Sarah Kim (Author), Michael M. Swarbrick (Author), Jingbao Li (Author), Sylvia J. Gasparini (Author), Joanne Thai (Author), Daphne Foong (Author), Lauryn L. Cavanagh (Author), Colette Fong-Yee (Author), Elisabeth Karsten (Author), Ruby C.Y. Lin (Author), Mark S. Cooper (Author), Hong Zhou (Author), Markus J. Seibel (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis. Previous studies have shown that skeletal glucocorticoid signalling increases with aging and that osteoblasts mediate the detrime...