Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9

• Main Authors: Koki Higashioka (Author), Noriko Koizumi (Author), Hidetoshi Sakurai (Author), Chie Sotozono (Author), Takahiko Sato (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well known that myogenic regulatory factors encoded by the Myod1 family of genes have pivotal roles in myogenesis, with partially overlapping functions, as demonstrated for the mouse embryo. Myogenin-mutant mice, however, exhibit severe myogenic defects without compensation by other myogenic f...