Biomaterial-Mediated Protein Expression Induced by Peptide-mRNA Nanoparticles Embedded in Lyophilized Collagen Scaffolds

• Autores principales: Rik Oude Egberink (Autor), Helen M. Zegelaar (Autor), Najoua El Boujnouni (Autor), Elly M. M. Versteeg (Autor), Willeke F. Daamen (Autor), Roland Brock (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

In our aging society, the number of patients suffering from poorly healing bone defects increases. Bone morphogenetic proteins (BMPs) are used in the clinic to promote bone regeneration. However, poor control of BMP delivery and thus activity necessitates high doses, resulting in adverse effects and...