Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress

• Main Authors: Mohamed H. Elsherbeny (Author), Jushin Kim (Author), Noha A. Gouda (Author), Lizaveta Gotina (Author), Jungsook Cho (Author), Ae Nim Pae (Author), Kyeong Lee (Author), Ki Duk Park (Author), Ahmed Elkamhawy (Author), Eun Joo Roh (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoamine oxidase B (MAO-B) is responsible for dopamine metabolism and plays a key role in oxidative stress by changing the redox state of neuronal and glial cells. To date, no disease-modifying therapy for Parkinson's disease (PD) has been identified. However, MAO-B inhibitors have emerged as...