Highly Potent, Selective, and Competitive Indole-Based MAO-B Inhibitors Protect PC12 Cells against 6-Hydroxydopamine- and Rotenone-Induced Oxidative Stress

• Những tác giả chính: Mohamed H. Elsherbeny (Tác giả), Jushin Kim (Tác giả), Noha A. Gouda (Tác giả), Lizaveta Gotina (Tác giả), Jungsook Cho (Tác giả), Ae Nim Pae (Tác giả), Kyeong Lee (Tác giả), Ki Duk Park (Tác giả), Ahmed Elkamhawy (Tác giả), Eun Joo Roh (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2021-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Monoamine oxidase B (MAO-B) is responsible for dopamine metabolism and plays a key role in oxidative stress by changing the redox state of neuronal and glial cells. To date, no disease-modifying therapy for Parkinson's disease (PD) has been identified. However, MAO-B inhibitors have emerged as...