Direct detection and identification of active pharmaceutical ingredients in intact tablets by helium plasma ionization (HePI) mass spectrometry

• Autori principali: Athula B. Attygalle (Autore), Freneil B. Jariwala (Autore), Julius Pavlov (Autore), Zhihua Yang (Autore), Jason A. Mahr (Autore), Mabel Oviedo (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2014-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A simple modification converts an electrospray ion source to an ambient-pressure helium plasma ionization source without the need of additional expensive hardware. Peaks for active ingredients were observed in the spectra recorded from intact pharmaceutical tablets placed in this source. A flow of h...