Ascertaining the burden of invasive Salmonella disease in hospitalised febrile children aged under four years in Blantyre, Malawi.

• Main Authors: Chisomo L Msefula (Author), Franziska Olgemoeller (Author), Ndaru Jambo (Author), Dalitso Segula (Author), Trinh Van Tan (Author), Tonney S Nyirenda (Author), Wilfred Nedi (Author), Neil Kennedy (Author), Matthew Graham (Author), Marc Y R Henrion (Author), Stephen Baker (Author), Nicholas Feasey (Author), Melita Gordon (Author), Robert S Heyderman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typhoid fever is endemic across sub-Saharan Africa. However, estimates of the burden of typhoid are undermined by insufficient blood volumes and lack of sensitivity of blood culture. Here, we aimed to address this limitation by exploiting pre-enrichment culture followed by PCR, alongside routine blo...