Studies on tissue distribution of scutellarin and methyl polyethylene glycol (mPEG)-scutellarin prodrug in mice

• Main Authors: Juan Lu (Author), Xia Zhan (Author), Qingfei Liu (Author), Xi Chen (Author), Xinge Zhao (Author), Yiming Wang (Author), Guoan Luo (Author)
• Format: Book
• Published: Elsevier, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was to determine tissue distribution and pharmacokinetics of mPEG-scutellarin prodrug (7e), a chemical entity previously shown to have a beneficial effect in cerebral ischemia/reperfusion (I/R) injury. After injecting scutellarin or prodrug 7e, the concentrations of scutellarin and 7e in...