Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2

• Main Authors: Saba R. Aliyari (Author), Amir Ali Ghaffari (Author), Olivier Pernet (Author), Kislay Parvatiyar (Author), Yao Wang (Author), Hoda Gerami (Author), Ann-Jay Tong (Author), Laurent Vergnes (Author), Armin Takallou (Author), Adel Zhang (Author), Xiaochao Wei (Author), Linda D. Chilin (Author), Yuntao Wu (Author), Clay F. Semenkovich (Author), Karen Reue (Author), Stephen T. Smale (Author), Benhur Lee (Author), Genhong Cheng (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I) trigger a signaling cascade that culminates in t...