NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

• Main Authors: Elisabeth Hessmann (Author), Jin-San Zhang (Author), Nai-Ming Chen (Author), Marie Hasselluhn (Author), Geou-Yarh Liou (Author), Peter Storz (Author), Volker Ellenrieder (Author), Daniel D. Billadeau (Author), Alexander Koenig (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acinar transdifferentiation toward a duct-like phenotype constitutes the defining response of acinar cells to external stress signals and is considered to be the initial step in pancreatic carcinogenesis. Despite the requirement for oncogenic Kras in pancreatic cancer (PDAC) development, oncogenic K...