Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

• Główni autorzy: Tiffany S. Dwyer (Autor), Joseph B. O'Brien (Autor), Christopher P. Ptak (Autor), Justin E. LaVigne (Autor), Daniel P. Flaherty (Autor), Val J. Watts (Autor), David L. Roman (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction in responses to inflammatory pain. Previous drug...