Chitosan-Based Thermogelling System for Nose-to-Brain Donepezil Delivery: Optimising Formulation Properties and Nasal Deposition Profile

• Main Authors: Mirna Perkušić (Author), Laura Nižić Nodilo (Author), Ivo Ugrina (Author), Drago Špoljarić (Author), Cvijeta Jakobušić Brala (Author), Ivan Pepić (Author), Jasmina Lovrić (Author), Maša Safundžić Kučuk (Author), Marie Trenkel (Author), Regina Scherließ (Author), Dijana Zadravec (Author), Livije Kalogjera (Author), Anita Hafner (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donepezil nasal delivery strategies are being continuously investigated for advancing therapy in Alzheimer's disease. The aim of this study was to develop a chitosan-based, donepezil-loaded thermogelling formulation tailored to meet all the requirements for efficient nose-to-brain delivery. A s...