Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

• Main Authors: Sameera Senaweera (Author), Tiffany C. Edwards (Author), Jayakanth Kankanala (Author), Yan Wang (Author), Rajkumar Lalji Sahani (Author), Jiashu Xie (Author), Robert J. Geraghty (Author), Zhengqiang Wang (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current drugs for treating human cytomegalovirus (HCMV) infections are limited by resistance and treatment-associated toxicities. In developing mechanistically novel HCMV antivirals, we discovered an N-benzyl hydroxypyridone carboxamide antiviral hit (8a) inhibiting HCMV in submicromolar range. We d...