Monitoring Cellular Movement with Photoconvertible Fluorescent Protein and Single-Cell RNA Sequencing Reveals Cutaneous Group 2 Innate Lymphoid Cell Subtypes, Circulating ILC2 and Skin-Resident ILC2

• Main Authors: Minori Nakatani-Kusakabe (Author), Koubun Yasuda (Author), Michio Tomura (Author), Makoto Nagai (Author), Kiyofumi Yamanishi (Author), Etsushi Kuroda (Author), Nobuo Kanazawa (Author), Yasutomo Imai (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously generated a transgenic mouse line expressing skin-specific IL-33 (IL33tg mice) and showed that IL-33 elicits group 2 innate lymphoid cell (ILC2)-dependent atopic dermatitis-like skin inflammation. ILC2s are believed to be tissue-resident cells under steady-state conditions, but the dyn...