Integrated transcriptomics and metabolomics analysis of the hippocampus reveals altered neuroinflammation, downregulated metabolism and synapse in sepsis-associated encephalopathy

• Main Authors: Kejia Xu (Author), Hui Li (Author), Bing Zhang (Author), Meini Le (Author), Qiong Huang (Author), Rao Fu (Author), Giorgia Croppi (Author), Gang Qian (Author), Junjie Zhang (Author), Guangming Zhang (Author), Yinzhong Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sepsis-associated encephalopathy (SAE) is an intricated complication of sepsis that brings abnormal emotional and memory dysfunction and increases patients' mortality. Patients' alterations and abnormal function seen in SAE occur in the hippocampus, the primary brain region responsible for...