Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling

• Main Authors: Ali Mahdi (Author), Yahor Tratsiakovich (Author), John Tengbom (Author), Tong Jiao (Author), Lara Garib (Author), Michael Alvarsson (Author), Jiangning Yang (Author), John Pernow (Author), Zhichao Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well established that altered purinergic signaling contributes to vascular dysfunction in type 2 diabetes (T2D). Red blood cells (RBCs) serve as an important pool for circulating ATP and the release of ATP from RBCs in response to physiological stimuli is impaired in T2D. We recently demonstra...