Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis

• Main Authors: Giuseppe Taurino (Author), Ruhi Deshmukh (Author), Victor H. Villar (Author), Martina Chiu (Author), Robin Shaw (Author), Ann Hedley (Author), Engy Shokry (Author), David Sumpton (Author), Erica Dander (Author), Giovanna D'Amico (Author), Ovidio Bussolati (Author), Saverio Tardito (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™, a physiological medium with the concentrations of nutrient...