Drug-drug interactions of icenticaftor (QBW251) with a 5‐probe cytochrome P450 cocktail and oral contraceptives

• मुख्य लेखकों: Felix Huth (लेखक), Ulrike Glaenzel (लेखक), Anton Drollmann (लेखक), Wendy Weis (लेखक), Julia Zack (लेखक), Lidiya Bebrevska (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract A drug-drug interaction (DDI) study was conducted to evaluate the effect of icenticaftor (QBW251) on the pharmacokinetics (PK) of a 5‐probe cytochrome P450 (CYP) substrate cocktail, guided by in vitro studies in human hepatocytes and liver microsomes. Another DDI study investigated the effe...