Drug-drug interactions of icenticaftor (QBW251) with a 5‐probe cytochrome P450 cocktail and oral contraceptives

• Автори: Felix Huth (Автор), Ulrike Glaenzel (Автор), Anton Drollmann (Автор), Wendy Weis (Автор), Julia Zack (Автор), Lidiya Bebrevska (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2024-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract A drug-drug interaction (DDI) study was conducted to evaluate the effect of icenticaftor (QBW251) on the pharmacokinetics (PK) of a 5‐probe cytochrome P450 (CYP) substrate cocktail, guided by in vitro studies in human hepatocytes and liver microsomes. Another DDI study investigated the effe...