Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan
Purpose. To investigate the role of intestinal breast cancer resistant protein (BCRP) in the absorption and disposition of topotecan (TPT) using novobiocin (NOV) as a specific inhibitor. Methods. Transporter inhibition specificity of NOV was assessed in cells overexpressing BCRP or Pgp. Sprague-Dawl...
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Frontiers Media S.A.,
2007-10-01T00:00:00Z.
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Internet
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A1234.567 |
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| Kopie 1 | Beschikbaar |