Clinical evaluation of the lot-to-lot consistency of an enterovirus 71 vaccine in a commercial-scale phase IV clinical trial

• Main Authors: Jinhua Chen (Author), Pengfei Jin (Author), Xiaoqi Chen (Author), Qunying Mao (Author), Fanyue Meng (Author), Xinguo Li (Author), Wei Chen (Author), Meizhi Du (Author), Fan Gao (Author), Pei Liu (Author), Xiujuan Li (Author), Changfu Guo (Author), Tingbo Xie (Author), Weiwei Lu (Author), Qingliang Li (Author), Li Li (Author), Xing Yan (Author), Xiang Guo (Author), Hongqiao Du (Author), Xiuling Li (Author), Kai Duan (Author), Fengcai Zhu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To evaluate the immunogenicity, safety and lot-to-lot consistency of an inactivated enterovirus 71 (EV71) vaccine cultured in bioreactors with different specifications after full immunization. Methods A randomized, double-blind trial was performed in 3,000 children aged 6 ~ 35 months with...