Evidence against a role for NLRP3-driven islet inflammation in db/db mice

• Main Authors: H.L. Kammoun (Author), T.L. Allen (Author), D.C. Henstridge (Author), S. Barre (Author), R.C. Coll (Author), G.I. Lancaster (Author), L. Cron (Author), S. Reibe (Author), J.Y. Chan (Author), M. Bensellam (Author), D.R. Laybutt (Author), M.S. Butler (Author), A.A.B. Robertson (Author), L.A. O'Neill (Author), M.A. Cooper (Author), M.A. Febbraio (Author)
• Format: Book
• Published: Elsevier, 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure in T2D. Specific targeting of the NLRP3 inflammasome to prevent pancreatic β...