Evidence against a role for NLRP3-driven islet inflammation in db/db mice
Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure in T2D. Specific targeting of the NLRP3 inflammasome to prevent pancreatic β...
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Elsevier,
2018-04-01T00:00:00Z.
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