Evidence against a role for NLRP3-driven islet inflammation in db/db mice

• 主要な著者: H.L. Kammoun (著者), T.L. Allen (著者), D.C. Henstridge (著者), S. Barre (著者), R.C. Coll (著者), G.I. Lancaster (著者), L. Cron (著者), S. Reibe (著者), J.Y. Chan (著者), M. Bensellam (著者), D.R. Laybutt (著者), M.S. Butler (著者), A.A.B. Robertson (著者), L.A. O'Neill (著者), M.A. Cooper (著者), M.A. Febbraio (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2018-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β cell failure in T2D. Specific targeting of the NLRP3 inflammasome to prevent pancreatic β...